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Additional file 3 of Unveiling role of sphingosine-1-phosphate receptor 2 as a brake of epithelial stem cell proliferation and a tumor suppressor in colorectal cancer

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posted on 2021-04-16, 10:48 authored by Luciana Petti, Giulia Rizzo, Federica Rubbino, Sudharshan Elangovan, Piergiuseppe Colombo, Silvia Restelli, Andrea Piontini, Vincenzo Arena, Michele Carvello, Barbara Romano, Tommaso Cavalleri, Achille Anselmo, Federica Ungaro, Silvia D’Alessio, Antonino Spinelli, Sanja Stifter, Fabio Grizzi, Alessandro Sgambato, Silvio Danese, Luigi Laghi, Alberto Malesci, Stefania Vetrano
Additional file 3: Supplementary Figure 3. Analysis of survival rate of the colonic mucosa of S1PR2−/− and S1PR2+/+ mice after AOM/DSS induced colitis-associated cancer. The tissues (healthy and tumor regions) were evaluated by immunohistochemical analysis with an anti-cleaved caspase-3 antibody. The images were acquired by the DotSlide system at 20x objective. Apoptotic cells (blue arrows) were examined microscopically at 40X magnification. Data are presented as the mean ± SEM, and significance was evaluated by the Mann-Whitney test. Data is representative of 2 experiments (n = 6).

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Fondazione Cariplo per la ricerca Associazione Italiana Contro le Leucemie - Linfomi e Mieloma Fondazione Umberto Veronesi Esprinet SpA (IT)

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