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Additional file 3 of PDGFRβ is an essential therapeutic target for BRCA1-deficient mammary tumors

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posted on 2021-01-23, 00:46 authored by Feng Bai, Shiqin Liu, Xiong Liu, Daniel P. Hollern, Alexandria Scott, Chuying Wang, Lihan Zhang, Cheng Fan, Li Fu, Charles M. Perou, Wei-Guo Zhu, Xin-Hai Pei
Additional file 3 Brca1-deficient mouse mammary tumors express high level of Pdgfrβ and are metastatic. (A) Representative immunostaining of a p16-/-;Brca1MGKO mammary tumor and its lung metastasis (M) with antibodies against Pdgfrβ (Green) and Ck14 (Red). Note the widely expressed Pdgfrβ in primary and metastasized tumors that are Ck14 positive. (B) Representative immunostaining of an additional p18-/-;Brca1MGKO mammary tumor.

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National Natural Science Foundation of China Guangdong Provincial Science and Technology Program High Energy Physics Group, University of Mississippi (US) Natural Science Foundation of Guangdong Province DOD Idea Expansion Award American Cancer Society

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    Breast Cancer Research

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    BRCA1PDGFRβEMTMammary tumorTargeted therapy

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