13059_2021_2516_MOESM3_ESM.docx (2.72 MB)
Additional file 3 of Lamin C is required to establish genome organization after mitosis
journal contribution
posted on 2021-11-15, 04:10 authored by Xianrong Wong, Victoria E. Hoskins, Ashley J. Melendez-Perez, Jennifer C. Harr, Molly Gordon, Karen L. ReddyAdditional file 3. Review history
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National Institutes of Health
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raising intriguing questionsexamine chromosome architectureoverall chromosome organizationnascent nuclear envelopemitosis abstract backgrounddynamic 3d organizationunexpectedly central rolepredominant lamins involvedmitotic lad associationmitotic ne associationestablish genome organizationlamin c remainslamin c associationcells exit mitosis3d organizationperipheral associationgenome organizationnuclear peripherylamin cmouse cellsmammalian cellslad segregationlad scaffoldingchromosomal ladcells depletedwhereas laminstriking differencesseveral hoursoverlapping roleskey regulatorincluding intergene regulationevidence suggestseuchromatic regionsdifferential phosphorylationcorrelates temporallycellular functionassociated domains
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