13148_2021_1176_MOESM2_ESM.pdf (1.5 MB)
Additional file 2 of DNA methylation profiling identifies two distinct subgroups in breast cancers with low hormone receptor expression, mainly associated with HER2 amplification status
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posted on 2021-10-04, 03:09 authored by Philipp Jurmeister, Karsten Weber, Sonia Villegas, Thomas Karn, Michael Untch, Anne Thieme, Volkmar Müller, Eliane Taube, Peter Fasching, Wolfgang D. Schmitt, Frederik Marmé, Elmar Stickeler, Bruno V. Sinn, Paul Jank, Christian Schem, Frederick Klauschen, Marion van Mackelenbergh, Carsten Denkert, Sibylle Loibl, David CapperAdditional file 2. Fig. S2: Flowchart showing the composition of the study cohort with samples from the publicly available “The Cancer Genome Atlas” (TCGA) dataset as well as specimens from the clinical GeparSixto and GeparSepto trial. Abbreviations: BRCA = breast cancer; ER = estrogen receptor; PR = progesterone receptor; TNBC = triple negative breast cancer; t-SNE = t-distributed stochastic neighbor embedding.
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Deutsches Konsortien für Krebsforschung Deutsche Krebshilfe
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ki67 proliferation indeximportant patient subgrouphormone receptor positivehormone receptor expressiondata strongly suggestclinical outcome parametersclinical data showcancer genome atlasworse outcome comparedher2 amplification groupedclinically closely related1 – 10“ lowhr hrposincluding 13 samples“ lowhr tnbcher2 amplificationclosely relatedlowhr hrposreference sampleslike sampleslowhr tnbcunsupervised clusteringtumor cellsmainly associatedlike ”).like casesdimensionality reductionbreast cancers10 %.
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