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Additional file 20 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

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posted on 2021-08-11, 03:34 authored by Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M. Hautbergue
Additional file 20 : Supplementary Figure 6. Orthologous genes in the human and fly genomes. BioMart ( http://www.ensembl.org/biomart/martview ) Ensembl Genes 99 was used with the Homo sapiens GRCh38.p13 and the Drosophila melanogaster BDGP6.28 genomes. A multispecies comparison was performed on 25.04.2020 based on (i) Homologue filters, Orthologous genes only or (ii) Homologue filters, Orthologous human Genes only. (A) 3681 human coding genes out of 20,449 have conserved fly orthologous genes. (B) 3411 fly coding genes of 13,947 have conserved human orthologous genes. List of orthologous genes are available upon request.

Funding

Motor Neurone Disease Association Biotechnology and Biological Sciences Research Council Medical Research Council Royal Society International Research and Exchanges grant Fondation Thierry Latran Academy of Medical Sciences Springboard Award H2020 European Research Council Alzheimer's Research UK NIHR Sheffield Biomedical Research Centre

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    Molecular Neurodegeneration

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    Keywords

    Amyotrophic lateral sclerosisC9ORF72-repeat expansionsPre-clinical modelsTranscriptomeGenome-wide mechanisms of neuroprotectionSRSF1-dependent RNA nuclear exportDisease-modifying gene expression signatureVoltage-gated potassium ion channel

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