13059_2021_2562_MOESM1_ESM.pdf (343.43 kB)
Additional file 1 of sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies
journal contribution
posted on 2022-01-25, 05:14 authored by Reza Nasirigerdeh, Reihaneh Torkzadehmahani, Julian Matschinske, Tobias Frisch, Markus List, Julian Späth, Stefan Weiss, Uwe Völker, Esa Pitkänen, Dominik Heider, Nina Kerstin Wenke, Georgios Kaissis, Daniel Rueckert, Tim Kacprowski, Jan BaumbachAdditional file 1 Experimental details.Table S1. The SHIP case study. Table S2.. The COPDGene case study. Table S3. The FinnGen case study. Supplementary results.Figure S1. The significant SNPs overlapped between sPLINK and PLINK for the SHIP case study considering Bonferroni significance threshold. Figure S2. The Spearman rank correlation coefficient between the p-values from each tool and the aggregated analysis for the COPDGene and FinnGen case studies. Figure S3. Runtime and network bandwidth usage of sPLINK with varying number of SNPs. Figure S4. Runtime and network bandwidth usage of sPLINK with varying number of samples. Figure S5. Runtime and network bandwidth usage of sPLINK with varying number of clients. Experimental setup.Table S4. The system specification of the physical machines and laptops used to measure the runtime and network bandwidth usage of sPLINK. Table S5. The experimental setup used for measuring the runtime and network bandwidth usage of sPLINK.
