Additional file 1 of Turing miRNA into infinite coordination supermolecule: a general and enabling nanoengineering strategy for resurrecting nuclear acid therapeutics

Additional file 1. Figure S1. Vis-UV spectrum of RNA (miR-30C) and IacsRNA (Iacs-miR-30C). Figure S2. Gene set enrichment analysis (GSEA) showing the cell cycle checkpoints and cell cycle mitotic differentially expressed in response to IacsRNA. Figure S3. Cell cycle of B16F10 cells after 1-day miR-30C and Iacs-miR-30C treatment at a dosage of 100 nM. Figure S4. Representative IF staining for Bcl9 and IHC staining for β-catenin in B16F10 tumors with different treatments. Figure S5. Representative IF staining for c-Myc and Cyclin D1 in B16F10 tumors with different treatments. Table S1. Hydrodynamic diameter at different pH values measured by DLS. Supplementary experimental section.