Additional file 1 of TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression

Additional file 1: Supplementary Fig 1. (Supplemental to Fig. 1) AGPS is down-regulated in prostate cancer and negatively correlated with prognosis. Supplementary Fig 2. (Supplemental to Fig. 2) AGPS inhibits the proliferation of PC-3 cells. Supplementary Fig 3. (Supplemental to Fig. 3) MDM2 inhibits ferroptosis through regulating AGPS- a p53-independent pathway. Supplementary Fig 4. (Supplemental to Fig. 6) TrkA has a significant effect on the stability of the protein of AGPS. Supplementary Fig 5. (Supplemental to Fig. 7) Effectiveness of the combination of  ML210 and Larotrectinib, in the PC3 cell line. Supplementary Table 1.Oligonucleotides used for relative gene expression by qRT-PCR. Supplementary Table 2. The oligonucleotides of si- or sh- RNAs.