40164_2024_492_MOESM1_ESM.pdf (5.98 MB)
Additional file 1 of The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice
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posted on 2024-02-27, 04:40 authored by Daishi Ishihara, Atsushi Hasegawa, Ikuo Hirano, James Douglas Engel, Masayuki Yamamoto, Ritsuko ShimizuSupplementary Material 1
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Japan Society for the Promotion of Science Japan Agency for Medical Research and Development
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study provides evidencelevels significantly exceedingdose dependent manneradditional genetic modificationsprogenitors remains smallmegakaryocyte progenitors insufficientlyterminal transactivation domainsomatic gata1 mutationsenabling megakaryocytic progenitorsgata1s correlates wellacute megakaryoblastic leukemiaprogenitors persistedterminal maturationmegakaryocytic lineageslength gata1gata1 isoformendogenous gata1young adultstransgenic increasematuration blockleukemic predispositionincreased probabilityimmature megakaryocytesgata1s supportsgata1s appearfully differentiateexhibit hyperproliferationexclusive productiondelicate balanceclinical observation
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