Additional file 1 of Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor

Giang, Le Hien; Wu, Kuo-Sheng; Lee, Wei-Chung; Chu, Shing-Shung; Do, Anh Duy; Changou, Chun A.; Tran, Huy Minh; Hsieh, Tsung-Han; Chen, Hsin-Hung; Hsieh, Chia-Ling; Sung, Shian-Ying; Yu, Alice L.; Yen, Yun; Wong, Tai-Tong; Chang, Che-Chang

doi:10.6084/m9.figshare.24883461.v1

13046_2023_2911_MOESM1_ESM.docx (1.96 MB)

Additional file 1 of Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor

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posted on 2023-12-21, 05:00 authored by Le Hien Giang, Kuo-Sheng Wu, Wei-Chung Lee, Shing-Shung Chu, Anh Duy Do, Chun A. Changou, Huy Minh Tran, Tsung-Han Hsieh, Hsin-Hung Chen, Chia-Ling Hsieh, Shian-Ying Sung, Alice L. Yu, Yun Yen, Tai-Tong Wong, Che-Chang Chang

Additional file 1: Figure S1. Expression of candidate genes in ATRT and the essential of RRM2 for ATRT cell lines survival. Figure S2. Knockdown of RRM2 suppressed cell proliferation in the CHLA266 cell line. Figure S3. COH29 showed an anticancer effect on CHLA266 cells. Figure S4. Body weight of ATRT mice. Figure S5. COH29 treatment induced apoptosis in ATRT cells. Figure S6. COH29 treatment activated DNA damage in ATRT cells. Figure S7. The correlation of RNA expression between SMARCB1 and RRM2, BRCA1.

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National Science and Technology Council Ministry of Education Health Promotion Administration, Ministry of Health and Welfare

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prolong overall survival poor survival rates poor prognostic conditions molecular profiling analysis central nervous system pronounced inhibitory effect novel therapeutic approach clinical data analysis atrt colony formation vitro experiments showed rrm2 transcriptional activation despite aggressive treatment atrt cell lines coh29 treatment led therapeutic potential promising effect clinical trials cell proliferation aggressive malignancy treat atrt atrt suggests atrt cells western blot strongly correlated silence rrm2 significantly overexpressed significantly decrease several cancers rrm2 inhibitor ribonucleotide reductase results rrm2 provide evidence predominantly occurring potential suitability pdx tissues oncogenic functions methods expression genomic instability feasible strategies expression level employed shrnas effective drugs early childhood conclusions collectively comprehensive bioinformatics coh29 resulted

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Additional file 1 of Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor

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National Science and Technology Council Ministry of Education Health Promotion Administration, Ministry of Health and Welfare

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