12964_2023_1437_MOESM1_ESM.docx (394.61 kB)
Additional file 1 of Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis
journal contribution
posted on 2024-02-22, 04:40 authored by Soumyadeep Sarkar, Cailin Deiter, Jennifer E. Kyle, Michelle A. Guney, Dylan Sarbaugh, Ruichuan Yin, Xiangtang Li, Yi Cui, Mireia Ramos-Rodriguez, Carrie D. Nicora, Farooq Syed, Jonas Juan-Mateu, Charanya Muralidharan, Lorenzo Pasquali, Carmella Evans-Molina, Decio L. Eizirik, Bobbie-Jo M. Webb-Robertson, Kristin Burnum-Johnson, Galya Orr, Julia Laskin, Thomas O. Metz, Raghavendra G. Mirmira, Lori Sussel, Charles Ansong, Ernesto S. NakayasuAdditional file 1: Figure S1. Abundance of selected proteins from proteomics analysis of 3 common models used for the study of β-cell stress in type 1 diabetes: A EndoC-βH1 cells exposed to IL-1β and INF-γ for 48 h (n = 3), B human islets exposed to same cytokines for 24 h (n = 10) and C islets from non-obese diabetic (NOD) mice in pre-diabetic stage (6 weeks of age) vs. age-matched NOR mice (n = 3). Abbreviations: GBP2: interferon-induced guanylate-binding protein 2, Stat1: signal transducer and activator of transcription 1, TAP1: antigen peptide transporter 1. Statistical test: ** p ≤ 0.01 and *** p ≤ 0.001 by t-test considering equal distribution and variance.
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polyunsaturated fatty acidslipidomic analyses showedinflammatory cytokines interlukinedata provide insights3 fatty acids3 fatty acidimaging assays showedmediated cytokine signalingislet lipid compositionmechanism involves omegaprotective mechanismfluorescence imagingdownstream signalingvideo abstractunderlying mechanismstriacylglycerol speciesthree modelsspecific factorresults acrosspoorly understoodobese micemediated reductionlysophosphatidylcholine specieslipidomics landscapediabetic nonconsistent increasecell deathapoptotic assay
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