40478_2021_1162_MOESM1_ESM.docx (2.18 MB)
Additional file 1 of Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice
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posted on 2021-04-02, 03:58 authored by Tahir Ali, Samia Hannaoui, Satish Nemani, Waqas Tahir, Irina Zemlyankina, Pearl Cherry, Su Yeon Shim, Valerie Sim, Hermann M. Schaetzl, Sabine GilchAdditional file 1. Supplementary Information.
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Canadian Institute of Health Research Alberta Prion Research Institute Alberta Innovates - Health Solutions Canada Research Chairs
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Cyp 46A activator efavirenzmitigated PrPSc propagationFDAimpact prion conversionCyp 46A increases survival timesCyp 46A levelsprion diseasesintracerebral prion inoculationmice Abstract Prion diseasescholesterol 24- hydroxylaselipid raft integrityprion-infectedCYP 46A Cyp 46A converts cholesterolblood brain barrierHIVanti-retroviral medication EFV
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