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Additional file 1 of Loss of H3K27 trimethylation is frequent in IDH1-R132H but not in non-canonical IDH1/2 mutated and 1p/19q codeleted oligodendroglioma: a Japanese cohort study

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posted on 2021-05-22, 03:35 authored by Umma Habiba, Hirokazu Sugino, Roumyana Yordanova, Koki Ise, Zen-ichi Tanei, Yusuke Ishida, Satoshi Tanikawa, Shunsuke Terasaka, Ken-ichi Sato, Yuuta Kamoshima, Masahiko Katoh, Motoo Nagane, Junji Shibahara, Masumi Tsuda, Shinya Tanaka
Additional file 1: Table S1. Correlation between H3K27me3 and ATRX immunoreactivity among gliomas; Figure S1. Decision tree of recursive partitioning model starting with IDH1-R132H staining followed by ATRX and H3K27me3 staining. Blue bars correspond to IDH Mut 1p/19q codeleted oligodendrogliomas, and orange bars correspond to not IDH Mut 1p/19q codeleted gliomas. We considered IDH Mut 1p/19q codeleted oligodendroglioma as a dependent variable and immunostaining (H3K27me3, ATRX, and IDH1-R132H) as predictors. NR nuclear retention, NL nuclear loss, Mut mutated.

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Ministry of Education, Culture, Sports, Science and Technology Japan Agency for Medical Research and Development

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    Acta Neuropathologica Communications

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    Keywords

    MutationWild typeTrimethylation at lysine 27 of histone 3Glioblastoma

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