13046_2024_2996_MOESM1_ESM.docx (26.76 kB)
Additional file 1 of KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma
journal contribution
posted on 2024-03-06, 04:40 authored by Hongshi Cai, Jianfeng Liang, Yaoqi Jiang, Ziyi Wang, Hongyu Li, Wenjin Wang, Cheng Wang, Jinsong HouSupplementary Material 1.
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National Natural Science Foundation of China Young Teacher Foundation of Sun Yat-sen University
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vivo experiments confirmedpotential therapeutic strategyneck squamous carcinomaluciferase reporter assayscancer genome atlascolony formation assayassociated transcriptional programassociated genes obtainedidentified hnscc cellupstream transcription factorspromoting cell proliferationklf7 regulates superexhibited aberrant expressionstudy identified igf2bp2driven igf2bp2 overexpressionigf2bp2 overexpression mediatedtranswell migration assaygene expression omnibusidentify hub genespromoting hnscc progressionassociated genesassociated geneklf7 exhibitedstudy revealsstudy aimedigf2bp2 transcriptionigf2bp2 promotescas9 genehub seincreased expressionhigh expressioninvasion assaymanaging hnscchnscc tissueshnscc cellsunfavorable prognosispositive correlationpoor prognosisperformed cckmolecule inhibitorsmolecular mechanismsmetastatic abilitiesmany typesmalignant progressionhigh aggressivenessgreatly contributesediting systemdirectly bind
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