posted on 2021-05-20, 03:27authored byDonna L. Nile, Colin Rae, David J. Walker, Joe Canning Waddington, Isabel Vincent, Karl Burgess, Mark N. Gaze, Robert J. Mairs, Anthony J. Chalmers
Additional file 1: Supplementary Figure S1. The effect of 2-DG and metformin on cell survival. Supplementary Figure S2. The radiosensitising effect of 2-DG and metformin as single agents. Supplementary Figure S3. The effect of combination treatment on glycolytic and mitochondrial metabolites. Supplementary Figure S4. Effects of 2-DG treatment on purine metabolism. Supplementary Figure S5. Effects of 2-DG treatment on pyrimidine metabolism. Supplementary Figure S6. The effect of combination treatment on mitochondrial respiration, glycolysis and cellular energy production. Supplementary Figure S7. The effect of combination treatment on mitochondrial respiration, glycolysis and cellular energy production. Supplementary Figure S8. The effect of 2-DG and metformin on the cell cycle. Supplementary Figure S9. The effect of combination treatment on apoptotic frequency.
Funding
CHILDREN with CANCER UK Wellcome Trust Cancer Research UK