Additional file 1 of Importance of circulating adipocytokines in multiple myeloma: a systematic review and meta-analysis based on case-control studies

Additional file 1: Table S1. Newcastle-Ottawa scale for the assessment of included studies. Table S2. Using GARDE to assess the credibility of the current evidence. Table S3. The pooled SMD and 95%CI of the eligible studies of leptin through sensitivity analysis. Table S4. The pooled SMD and 95%CI of the eligible studies of adiponectin through sensitivity analysis. Figure S1. Funnel plot for publication bias of the association between serum leptin levels and myeloma. Evident asymmetry was observed in the funnel plot, and the Egger’s test result was P=0.013, which indicates the existence of significant publication bias. Figure S2. Filled Funnel plot of the association between serum leptin levels and myeloma by the use of Trim and Fill method. Trim and Fill analysis was used to evaluate the effect of publication bias on the pooled result. The analysis showed the imputed pooled result was identical to our original result (SMD= 0.890, 95%CI: 0.337 to 1.442). No missing studies were added to the filled funnel plot.