13054_2021_3580_MOESM1_ESM.docx (2.49 MB)
Additional file 1 of Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort
journal contribution
posted on 2021-05-26, 03:34 authored by Pedro D. Wendel Garcia, Hernán Aguirre-Bermeo, Philipp K. Buehler, Mario Alfaro-Farias, Bernd Yuen, Sascha David, Thomas Tschoellitsch, Tobias Wengenmayer, Anita Korsos, Alberto Fogagnolo, Gian-Reto Kleger, Maddalena A. Wu, Riccardo Colombo, Fabrizio Turrini, Antonella Potalivo, Emanuele Rezoagli, Raquel Rodríguez-García, Pedro Castro, Arantxa Lander-Azcona, Maria C. Martín-Delgado, Herminia Lozano-Gómez, Rolf Ensner, Marc P. Michot, Nadine Gehring, Peter Schott, Martin Siegemund, Lukas Merki, Jan Wiegand, Marie M. Jeitziner, Marcus Laube, Petra Salomon, Frank Hillgaertner, Alexander Dullenkopf, Hatem Ksouri, Sara Cereghetti, Serge Grazioli, Christian Bürkle, Julien Marrel, Isabelle Fleisch, Marie-Helene Perez, Anja Baltussen Weber, Samuele Ceruti, Katharina Marquardt, Tobias Hübner, Hermann Redecker, Michael Studhalter, Michael Stephan, Daniela Selz, Urs Pietsch, Anette Ristic, Antje Heise, Friederike Meyer zu Bentrup, Marilene Franchitti Laurent, Patricia Fodor, Tomislav Gaspert, Christoph Haberthuer, Elif Colak, Dorothea M. Heuberger, Thierry Fumeaux, Jonathan Montomoli, Philippe Guerci, Reto A. Schuepbach, Matthias P. Hilty, Ferran Roche-CampoAdditional file 1. e-Appendix 1: Specifications on the RISC-19-ICU registry structure and data collection. e-Appendix 2: Missing data handling. e-Table 1: Overall “unmatched” baseline characteristics on Day 0. e-Figure 1: “Love Plot” presenting Standardized Mean Differences between the unmatched and matchedcohort. e-Table 2: Demographics, characteristics at ICU admission, progression of respiratory support and outcome; stratified by survivor status. e-Table 3: Progression of respiratory support stratified by respiratory support strategy at ICU admission. e-Figure 2: Temporal relationship between the period of admission to the intensive care unit and the use of respiratory support strategies or mortality rate. e-Figure 3: Kaplan Meier curves for intensive care unit mortality stratified by the period of admission to the intensive care unit. e-Table 4: Demographics, characteristics at ICU admission, progression of respiratory support and outcome for patients never requiring intubation and invasive mechanical ventilation. e-Figure 4: C-Reactive Protein stratified by respiratory support strategy on Day 0 over the first week of ICU stay. e-Table 5: Mixed Effect Model of C-Reactive Protein stratified by respiratory support strategy on Day 0 over the first week of ICU stay. e-Figure 5: Multivariable adjusted COX regression model for the incidence of intubation. e-Figure 6: Multivariable adjusted COX regression model for overall ICU mortality. e-Figure 7: Multivariable adjusted COX regression model for ICU mortality (intubated patients only). e-Figure 8: Multivariable adjusted COX regression model for ICU discharge (intubated patients only). e-Table 6: Prognostic Model for the identification of patients with lower ICU mortality risk after a failed HFNC or NIV trial. e-Figure 9: Nomogram, Receiver Operating Curves and stratified Kaplan Meier curve for a prognostic model identifying patients with lower ICU mortality risk after a failed HFNC or NIV trial. e-Table 7: Area Under the Receiver Operating Curves (AUROCs) for the Prognostic Score versus classic severity scores.
