Additional file 1 of Immune microenvironment changes induced by neoadjuvant chemotherapy in triple-negative breast cancers: the MIMOSA-1 study

Additional file 1: Table S1. Patients characteristics. Non-ductal histologic subtypes include one metaplastic chondroid (grade 2, no-pCR), one muco-epidermoid (grade 3, no-pCR) and one epidermoid metaplastic (grade 3, pCR). Abbreviations: D= docetaxel 100 mg/m2 (D1=D21), wP= weekly paclitaxel (80 mg/m2), (F)EC = 5-fluorouracil (500 mg/m2), epirubicin (100 mg/m2), cyclophosphamide (500 mg/m2). Table S2. Description of IME characteristics before and after chemotherapy, as a function of NACT response (pCR and no-pCR groups). Percentages for the pCR and no-pCR groups shown were calculated for each individual row. Table S3. Changes of IME characteristics induced by neoadjuvant chemotherapy, for the entire population, and as a function of the NACT response (pCR and no-pCR groups). Table S4. Overall survival at 3 years according to the initial clinical-pathological characteristics, as a function of core biopsy immune biomarkers (before chemotherapy) and vascular invasion evaluated on the surgical sample (after chemotherapy). Table S5. Association between overall survival (OS) and TILs, TIM-3 and LAG-3 evaluated as continuous variables.