Additional file 1 of Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice

Criado-Marrero, Marangelie; Gebru, Niat T.; Blazier, Danielle M.; Gould, Lauren A.; Baker, Jeremy D.; Beaulieu-Abdelahad, David; Blair, Laura J.

doi:10.6084/m9.figshare.14391487.v1

40478_2021_1159_MOESM1_ESM.docx (7.04 MB)

Additional file 1 of Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice

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posted on 2021-04-09, 03:26 authored by Marangelie Criado-Marrero, Niat T. Gebru, Danielle M. Blazier, Lauren A. Gould, Jeremy D. Baker, David Beaulieu-Abdelahad, Laura J. Blair

Additional file 1. Fig. S1: Overexpression of Aha1 or FKBP52 increases discrete phospho-tau species in aged wild-type mice. Additional insets from Figure 3 showing the CA1, CA3, and dentate gyrus (DG) from 16-months old wild-type mice expressing AAV9-mCherry, AAV9-Aha1, or AAV9-FKBP52 stained for (a) total tau (Dako), (b) pT231 tau, (c) AT8 (pS202/T205) tau, and (d) pS396 tau, as well as (e) T22 oligomeric tau and (f) Gallyas silver-positive tau. Scale bar represents 10 μm

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National Institute of Neurological Disorders and Stroke National Institute on Aging National Institute of Mental Health U.S. Department of Veterans Affairs Alzheimer's Association

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Tau FKBP52 Aha1 Molecular chaperones Alzheimer’s disease Neuroinflammation

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Additional file 1 of Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice

Funding

National Institute of Neurological Disorders and Stroke National Institute on Aging National Institute of Mental Health U.S. Department of Veterans Affairs Alzheimer's Association

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