Additional file 1 of HMGB1 mediates cognitive impairment caused by the NLRP3 inflammasome in the late stage of traumatic brain injury

Additonal file 1: Additional data and tables. Fig. S1. Additional data from behavioral experiments. (A-D) Nest building results for wild-type and NLPR3 knockout mice 4 weeks or 8 weeks post-TBI. (E–F) New object recognition results for wild-type and NLPR3 knockout mice 4 weeks or 8 weeks post-TBI. (G) T-maze results for wild-type and NLPR3 knockout mice 4 weeks or 8 weeks post-TBI. (H) The glycyrrhizin administration schedule and route for behavioral tests and the electrophysiological study (EPS). Data represent the means ± SD (n = 10 mice per group). ns (p > 0.05) compared to the WT group. Fig. S2. Location of slices and the brain areas (ROI) selected for the analysis of immunofluorescent in the stereotaxic atlas of the mouse brain. DG (Red), CA1 (Yellow), CA3 (Purple) and PFC (Blue). Table S1. Total number of mice used in the experiment. Table S2. Sample size calculation.