Additional file 1 of Estimated glucose disposal rate and risk of stroke and mortality in type 2 diabetes: a nationwide cohort study

Additional file 1: Table S1. Clinical characteristics of 24 male patients with type 2 diabetes who underwent a hyperinsulinaemic clamp procedure (CLAMP) and its comparison with estimated glucose disposal rate (eGDR) based on waist (eGDRwaist) and BMI (eGDRBMI), respectively. Table S2. 9th and 10th revision of international Classification of Diseases Codes (ICD-codes). Table S3. Hellers R2 (a measure of explained variance) calculated for HbA1c, waist, BMI and hypertension used as single main effects predictors in the Cox regression models (2). Table S4. Baseline characteristics of 205 482 patients with type 2 diabetes mellitus categorised in 4 groups of estimated glucose disposal rate (eGDR) based on BMI (eGDRBMI). Table S5. Event rates and relative risks for stroke, ischaemic stroke and haemorrhagic stroke, respectively, in 205 482 people with type 2 diabetes, stratified into four groups, depending on estimated glucose disposal rate (eGDR). Table S6. Event rates and relative risks unadjusted and adjusted for all-cause mortality and cardiovascular mortality in 205 482 people with type 2 diabetes, stratified into four groups, depending on estimated glucose disposal rate (eGDRBMI). Figure S1. Spearman association curves (r-value) between M-values for the hyperinsulinemic clamp (X-axis) and estimated glucose disposal rate (y-axis) based on waist (eGDRwaist) and BMI (eGDRBMI) top and bottom, respectively. Figure S2. Flowchart for the studied group. Figure S3. Adjusted hazard ratio (solid line) and 95% confidence intervals (dashed lines) for the association between baseline eGDR and stroke. The baseline eGDR level was modelled with restricted cubic splines in a Cox regression model adjusted for sex and age. Figure S4. Fully adjusted hazard ratios for stroke; on insulin treatment and not on insulin treatment, divided into all stroke (ischaemic and haemorrhagic stroke), ischaemic and haemorrhagic stroke, respectively in 104 697 individuals with type 2 diabetes according to eGDR (Reference eGDR <4). Figure S5. Cumulative incidence of stroke in in 205 482 patients with type 2 diabetes, divided into different groups depending on eGDRBMI. Figure S6. Hazard ratios for a first stroke, fully adjusted, divided into all stroke (ischaemic and haemorrhagic stroke), ischaemic and haemorrhagic stroke in 205 482 individuals with type 2 diabetes according to eGDRBMI (Reference eGDRBMI <4).