Additional file 1 of Duration of invasive mechanical ventilation prior to extracorporeal membrane oxygenation is not associated with survival in acute respiratory distress syndrome caused by coronavirus disease 2019

Additional file 1: Figure S1. Area plot of patient’s status over time. Figure S2. Survival probabilities plotted for all patients without LTX, grouped by pre-ECMO IMV duration with the cut-off point of 7 days. LTX = lung transplantation; ECMO = extracorporeal membrane oxygenation; IMV = invasive mechanical ventilation. Figure S3: Survival probabilities plotted for all patients without LTX, grouped by pre-ECMO IMV duration with the cut-off point of 10 days. LTX = lung transplantation; ECMO = extracorporeal membrane oxygenation; IMV = invasive mechanical ventilation. Table S1. Baseline laboratory values according to ICU mortality. All data are reported by median and IQR and compared using Man–Whitney U tests between groups; n gives the number of available observations. ProBNP = pro-brain natriuretic peptide; ALT = alanine aminotransferase; AST = aspartate aminotransferase; gamma-GT = gamma-glutamyl transferase; LDH = lactate dehydrogenase. Table S2. Effect of pre-ECMO IMV duration on hospital mortality in all patients with confounders age, modified SOFA score, comorbidities, and modified RESP score. IMV = invasive mechanical ventilation; ECMO = extracorporeal membrane oxygenation; SOFA = Sequential Organ Failure Assessment; PaO2 = partial pressure of arterial oxygen; FiO2 = fraction of inspired oxygen; RESP = respiratory ECMO survival prediction; ICU = intensive care unit. Table S3. Effect of pre-ECMO IMV duration on ICU mortality in all patients after exclusion of patients receiving LTX. IMV = invasive mechanical ventilation; ECMO = extracorporeal membrane oxygenation; ICU = intensive care unit; LTX = lung transplantation. Table S4. Effect of pre-ECMO IMV duration on ICU mortality in all patients with confounders age, modified SOFA score and modified RESP score after exclusion of patients receiving LTX. IMV = invasive mechanical ventilation; ECMO = extracorporeal membrane oxygenation; SOFA = Sequential Organ Failure Assessment; RESP = respiratory ECMO survival prediction; ICU = intensive care unit; LTX = lung transplantation. Table S5. Baseline characteristics for all patients by pre-ECMO IMV time. Metric data are reported by mean (± SD) or by median and IQR; n gives the number of available observations. IMV = invasive mechanical ventilation; ICU = intensive care unit; LTX = lung transplantation; BMI = body mass index; SOFA = Sequential Organ Failure Assessment. Table S6. Hazard ratios with confidence intervals from a Cox regression model after exclusion of patients receiving LTX. IMV = invasive mechanical ventilation; RESP = respiratory ECMO survival prediction; SOFA = Sequential Organ Failure Assessment. Table S7. ECMO-related adverse events. All data are reported by numbers and percentages; n gives the number of available observations. GI = gastrointestinal; ECMO = extracorporeal membrane oxygenation. Table S8. Effects of pre-ECMO IMV duration on the composed event ICU death or LTX. ICU = intensive care unit; LTX = lung transplantation; IMV = invasive mechanical ventilation; ECMO = extracorporeal membrane oxygenation. Table S9. Effect of pre-ECMO IMV duration on the composed event ICU death or LTX in all patients with confounders age, modified SOFA score, and underlying pulmonary disease. IMV = invasive mechanical ventilation; ECMO = extracorporeal membrane oxygenation; SOFA = Sequential Organ Failure Assessment; PaO2 = partial pressure of arterial oxygen; FiO2 = fraction of inspired oxygen.