12931_2023_2580_MOESM1_ESM.pdf (124.85 kB)
Additional file 1 of Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways
journal contribution
posted on 2023-11-01, 04:40 authored by Paulina Hempel, Virag Klein, Anna Michely, Svenja Böll, Annette D. Rieg, Jan Spillner, Till Braunschweig, Saskia von Stillfried, Norbert Wagner, Christian Martin, Klaus Tenbrock, Eva VerjansAdditional file 1: Figure S1. Amitriptyline (0.1–5 μM) is not toxic in rat PCLS. A LDH toxicity tests after 1h and B 24 h. n = 9 in all groups. Figure S2. Dilatation with IBMX/salbutamol and combinative therapies. A Minimal airway area after dilatation and stimulation with rising concentrations of methacholine. n = 4 in all groups. All graphs represent means ± SEM; *p < 0.05, ***p < 0.001.
