13059_2021_2539_MOESM1_ESM.pdf (1.56 MB)
Additional file 1 of A cis-regulatory-directed pipeline for the identification of genes involved in cardiac development and disease
journal contribution
posted on 2021-12-15, 04:35 authored by Hieu T. Nim, Louis Dang, Harshini Thiyagarajah, Daniel Bakopoulos, Michael See, Natalie Charitakis, Tennille Sibbritt, Michael P. Eichenlaub, Stuart K. Archer, Nicolas Fossat, Richard E. Burke, Patrick P. L. Tam, Coral G. Warr, Travis K. Johnson, Mirana RamialisonAdditional file 1: Fig S1. The cis-regulatory-directed bioinformatic pipeline for Psmd7 as an example. Fig S2. Distribution of gene expression values in the mouse embryonic heart E14.5. Fig S3. Properties of CREs. Fig S4. Overlap of predicted genes with genes harbouring de novo mutations associated with congenital heart disease. Fig S5. Expression and regulation of the experimentally validated genes. Table S1. List of genes that are regulated by enhancers and promoters specifically active in the heart, and known defects associated with these genes in human, and mouse and zebrafish models. Table S2. Evidence for new genes predicted to be involved in heart development or disease. Table S3. RNAi lines used for cardiac-specific knockdown in Drosophila.
