Additional file 1 of AUY922 induces retinal toxicity through attenuating TRPM1

Additional file 1: Figure S1. a Full-field electroretinogram (ffERG) of a patient with refractory gastrointestinal stromal tumor without AUY922 treatment. OD: right eye, OS: left eye. b Quantification of tumor volume in nude mice bearing xenograft tumors of A375 cells treated with mock (n = 6), 25 mg/kg AUY922 three times weekly (3qw, n = 6), or five times weekly (5qw, n = 6) for 2 w by intraperitoneal injection. Data are presented as the mean ± s.e.m. The P values were determined by two-tailed Student’s t-test, *** P < 0.001.c Body weight of the tumor-bearing mice in Figure S1b. Data are presented as the mean ± s.e.m. d Representative images of H&E staining of mouse eye samples from the AUY922 treatment experiment in Fig. 1b. Scale bar: 25 μm. n = 3. e Quantification of INL (left) and ONL (right) thickness of Figure S1d. The thickness of the INL and ONL was measured in H&E-stained sections at comparable locations. Data are presented as the mean ± s.e.m. Significances were determined by two-tailed Student’s t-test, ns: not significant. n = 3. f Non-cropped images of Fig. 1b. Boxed area was magnified, leveled, presented in Fig. 1b. bar: 25 μm.