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Additional file 11 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
journal contribution
posted on 2021-10-11, 03:14 authored by Marcus M. Soliai, Atsushi Kato, Britney A. Helling, Catherine T. Stanhope, James E. Norton, Katherine A. Naughton, Aiko I. Klinger, Emma E. Thompson, Selene M. Clay, Soyeon Kim, Juan C. Celedón, James E. Gern, Daniel J. Jackson, Matthew C. Altman, Robert C. Kern, Bruce K. Tan, Robert P. Schleimer, Dan L. Nicolae, Jayant M. Pinto, Carole OberAdditional file 11:. Supplementary methods describing the replication analysis of the molecular QTLs. Table S6: Percent of overlapping eQTL results with the URECA study. Table S7: Percent of overlapping meQTL results with the URECA study.
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National Institutes of Health Ernest S. Bazley Charitable Fund
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study provides evidencedna methylation dataepigenetic response mechanismsadult onset asthmamodulate genetic effects21 asthma locuswide association studiesused mendelian randomizationtreated upper aecsassociated gwas snpsspecific genetic mechanismspecific functional annotationschildhood onset asthmaasthma colocalized locimapped cis expressionaec molecular qtlsasthma risk variantswide geneticchildhood onsetfunctional effectsresults asthmavariants associatedtslp locusgene expressionethnic gwasepigenetic responsesepidemiological studiesspecific informationvariants discoveredtreatment conditionpromoting pathogenmediated transcriptionalincluding qtlsimmune diseasesidentified thousandshealthy participantsenvironmental factorsculture modelcomplex diseasescell typesbayesian testassess transcriptionalallergic diseaseaec qtls38 ).
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