pgen.1011159.s008.pdf (3.91 MB)
Acute estrogen treatment identifies direct ER target genes in T47D cells.
journal contribution
posted on 2024-02-20, 18:35 authored by Thomas G. Scott, Kizhakke Mattada Sathyan, Daniel Gioeli, Michael J. GuertinMA plot of PRO signal, with fold change values representing transcription in the 90 minute estrogen treatment condition relative to the DMSO condition. Each point represents a gene, and black points represent the estrogen-activated genes that we use in Fig 5.
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inducible degron tagcommon genetic variantsbreast cancer riskfamily transcription factorer redistribution leadshigh trps1 activityrelated gene setsdiv >< ptrps1 regulates transcriptioner target genesrepressing transcriptiontrps1 modulatestrps1 primary trps1taken togetherrepressive gataregulated genesprimary effectsparticularly sensitiveinducing degradationgenomic distributiongenes relatedestrogen signalingdirect targetsdata suggestcalculated usingacutely deplete80 percent
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