posted on 2022-01-05, 14:35authored byYijing Dang, Yi Lai, Fengping Chen, Qian Sun, Chunyong Ding, Wen Zhang, Zhiai Xu
Closely
related to multiple chronic inflammation, especially type-2
diabetes (T2D), methylglyoxal (MGO) may be a potential key to visualize
disease progression and treatment effects. On the other hand, lack
of convenient and fast analytical methods cannot afford accurate MGO
quantitative evaluation. In this work, an activatable second near-infrared
region (NIR-II) fluorescent probe TDTCD was synthesized and its reaction
mechanism with MGO was discussed. The desired NIR-II product preferred
response solvents with small polarity. A novel activatable nanoprobe,
MG-SLNP, for MGO was then constructed based on rational packaging
to provide a local nonpolar microenvironment. The hydrophobic core
of nanoparticles not only successfully improved the stability and
water solubility but also greatly promoted the response rate while
reacting with MGO. The comparison between NIR-II fluorescence and
the traditional high-performance liquid chromatography method for
T2D blood samples was discussed. A high-resolution viewing window,
quick response, and good biocompatibility led to a satisfactory signal-to-noise
ratio of MG-SLNP for real-time MGO bio-detection and imaging in vivo.