posted on 2021-06-18, 17:34authored byMin Li, Xi Lan, Ximei Han, Shuo Shi, Hao Sun, Yi Kang, Jie Dan, Jing Sun, Wentao Zhang, Jianlong Wang
Nanoantibacterial
agents based on catalytic activity were limited
due to the low levels of endogenous H2O2 in
the microenvironment of bacterial biofilms. However, the additional
H2O2 will trigger more side effects to healthy
surroundings, which is still a great challenge. Herein, we report
an acid-induced self-catalyzing platform based on dextran-coated copper
peroxide nanoaggregates (DCPNAs) for antibiofilm and local infection
therapy applications. The dextran-functionalized DCPNAs were mediated
and conveniently purified via a dextran and ethanol precipitation
method, which can also cluster nanodots into nanoaggregates and show
good penetrability as well as biocompatibility. Bacterial biofilms
were inhibited and destroyed by the reactive oxygen species generated
from the Fenton reaction between the Cu2+ and H2O2 released from DCPNAs in an acidic environment, which
did not require additional H2O2. As expected,
the DCPNAs exhibit low cytotoxicity and excellent acid-induced antibacterial
and antibiofilm ability. Moreover, the DCPNAs realized great therapeutic
outcomes in the application for in vivo wound healing. The overall
excellent properties associated with the DCPNAs highlight that they
could be considered as a kind of ideal antimicrobial agents for microbial
biofilm infection treatment.