posted on 2024-03-18, 17:41authored byYongbo Tan, Jing Zhao, Guo-Jun Deng, Xiaochen Ji, Huawen Huang
Herein, we introduce a tetralone-mediated photocyclization
method
of N-arylacrylamides. The protocol proceeds smoothly
to deliver a diverse set of 3,4-dihydroquinolinones in moderate to
good yields with excellent functional group compatibility and readily
allows for late-stage modifications of a number of complex drug molecules.
Mechanistic studies reveal that the present systems with ultraviolet
light irradiation enable the cyclization via energy transfer and exclusive
1,3-hydrogen shift.