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A Polymer-Supported Proline-Based Diamine Catalyst for the Kinetic Resolution of Racemic Secondary Alcohols

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journal contribution
posted on 2001-01-06, 00:00 authored by Bruce Clapham, Chang-Woo Cho, Kim D. Janda
The preparation of polymer-supported proline-based diamine catalyst 12 for the kinetic resolution of racemic mixtures of secondary alcohols is described. Not only is the catalyst effective for the resolution of a host of different alcohols, it can also be recovered and reused several times without loss of either activity or selectivity. The catalyst has been used in conjunction with a polymer-supported sequestration strategy, giving rise to an essentially pure mixture of resolved products that can be separated using flash chromatography.