posted on 2024-01-02, 15:35authored byBobo Cao, Haijun Yang, Zhiwu Yu
Structural
characterization of assemblies in solutions is essential
for understanding the relationship between the structure and material
properties. In this study, we introduce a novel approach to investigate
amphiphilic self-assemblies in solutions using the phospholipid molecule
1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine
(Lyso PC) as a 31P NMR probe. The high natural abundance
and gyromagnetic ratio of 31P make it one of the most sensitive
nuclei in the low-frequency region, enabling efficient detection even
in dilute solutions. Lyso PC can readily co-assemble with amphiphilic
molecules and ions in aqueous solutions, forming various structures,
such as hexagonal, lamellar, and micellar assemblies. The characteristic
line shapes of these assemblies reflect the chemical environment around
the probe and provide insights into the different phase states of
the assemblies. This strategy offers a simple, cost-effective, and
static method for obtaining structural information about various assemblies.
Our work not only introduces a sensitive probe for characterizing
assemblies in a solvent environment but also inspires new ideas for
the development of similar spectroscopic probes.