ABR data from the conditional knockout genotype control groups.

Newton, Sherylanne; Kong, Fanbo; Carlton, Adam J.; Aguilar, Carlos; Parker, Andrew; Codner, Gemma F.; Teboul, Lydia; Wells, Sara; Brown, Steve D. M.; Marcotti, Walter; Bowl, Michael R.

doi:10.1371/journal.pgen.1009937.s001

pgen.1009937.s001.docx (220.94 kB)

ABR data from the conditional knockout genotype control groups.

journal contribution

posted on 2022-01-31, 18:39 authored by Sherylanne Newton, Fanbo Kong, Adam J. Carlton, Carlos Aguilar, Andrew Parker, Gemma F. Codner, Lydia Teboul, Sara Wells, Steve D. M. Brown, Walter Marcotti, Michael R. Bowl

(A) Control data from Myo15-cre conditional cross compared alongside wild type Nptn^+/+;Myo15-cre^- mice (n = 5). Presence of the either the Myo15-cre allele (Nptn^fl/fl;Myo15-cre⁺, n = 5), or the floxed Nptn allele (Nptn^+/fl;Myo15-cre^-, n = 7 or Nptn^fl/fl;Myo15-cre^-, n = 6) did not affect ABR thresholds. (B) Control data from the Prestin-CreER^T2 conditional cross compared alongside wild type Nptn^+/+;Prestin-CreER^T2- with (n = 4) or without tamoxifen (n = 3). Mice dosed with tamoxifen had comparable ABR thresholds to those dosed with vehicle only. Presence of the Prestin-CreER^T2 allele did not alter ABR threshold (Nptn^+/+;Prestin-CreER^T2+;tamoxifen, n = 3). Moreover, mice carrying both alleles, but dosed with vehicle (Nptn^fl/fl;Prestin-CreER^T2+;vehicle, n = 4) also had normal ABR thresholds. Data are mean ± S.D.