posted on 2021-10-04, 15:08authored byAndisheh Motealleh, Andreas H. Schäfer, Olga Fromm, Nermin S. Kehr
Insufficient and heterogeneous oxygen
(O2) distribution
within engineered tissues results in hypoxic conditions. Hypoxia is
one of the characteristics of solid tumors. To date, very few studies
have used an O2-deliverable injectable hydrogel for cancer
treatment under hypoxic conditions. In this field, we describe a new
O2-carrying nanomaterial and an injectable nanocomposite
hydrogel (PMOF and AlgL-PMOF, respectively) that can provide extended
oxygen levels for cell survival under hypoxia. Particularly, PMOF
and AlgL-PMOF enhance cell viability under hypoxic and normoxic cell
culturing conditions. Moreover, sustained oxygen availability in the
presence of an anticancer drug within the 3D network of AlgL-PMOF
results in a decrease in the viability of malignant and immortal cells,
while the viability of healthy cells increases.