pgen.1011084.s005.tiff (358.45 kB)
mDia formins are required for cell recovery in 5-FU-induced myeloid suppression.
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posted on 2023-12-29, 21:01 authored by Zhaofeng Li, Meng Su, Xinshu Xie, Pan Wang, Honghao Bi, Ermin Li, Kehan Ren, Lili Dong, Zhiyi Lv, Xuezhen Ma, Yijie Liu, Baobing Zhao, Yuanliang Peng, Jing Liu, Lu Liu, Jing Yang, Peng Ji, Yang Mei(A) The numbers of HSPCs and committed progenitors from purified lineage-negative cells were analyzed and quantified by flow cytometer analysis by day 7 after 5-FU treatment. (B) Survival percentage of lineage-negative cells from A assayed by Annexin V staining. (C) Complete blood cell counts of wild-type or mDia1 KO mice were determined by day 7 after the first injection of 5-FU. (D) Kaplan-Meier survival analysis of indicated mice challenged with serial 5-FU injection. Error bars represent the SEM of the mean. * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001. Two-tailed unpaired student’s t-test was used to generate the p values.
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serum response factorlinear actin nucleationinvolved transcriptional signalingfilamentous actin networkmdia2 regulates enucleationmdia2 dad domainsmdia formins interplaymdia2 form heteromdia1 deficiency leadsmdia heterosignificant mortalitysevere anemiaserial platingrodent functionsregulate hematopoiesisprogenitor cellspotential rolespolymerization activitiesnewborn micemyeloid ablationmouse modelmdia1 gbdinduces myelodysplasiahspcs activityhspcs ).hspc regenerationhematopoietic stemdouble knockoutdeclined hspcsdata demonstrate
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