pgen.1011084.s002.tiff (163.87 kB)
mDia1 is not required for HSPCs homing to bone marrow.
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posted on 2023-12-29, 21:01 authored by Zhaofeng Li, Meng Su, Xinshu Xie, Pan Wang, Honghao Bi, Ermin Li, Kehan Ren, Lili Dong, Zhiyi Lv, Xuezhen Ma, Yijie Liu, Baobing Zhao, Yuanliang Peng, Jing Liu, Lu Liu, Jing Yang, Peng Ji, Yang Mei(A-C) WT or mDia1 KO BMMCs (A) or lineage-negative (CD45.2+) HSPCs (B-C) were mixed with equal wild-type CD45.1+ competitive cells and transplanted into lethally irradiated receipt mice (CD45.1+/CD45.2+). Bone marrow chimerism was determined 16 hours after transplantation. n = 4 per group for A, and n = 3 per group for B-C.
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serum response factorlinear actin nucleationinvolved transcriptional signalingfilamentous actin networkmdia2 regulates enucleationmdia2 dad domainsmdia formins interplaymdia2 form heteromdia1 deficiency leadsmdia heterosignificant mortalitysevere anemiaserial platingrodent functionsregulate hematopoiesisprogenitor cellspotential rolespolymerization activitiesnewborn micemyeloid ablationmouse modelmdia1 gbdinduces myelodysplasiahspcs activityhspcs ).hspc regenerationhematopoietic stemdouble knockoutdeclined hspcsdata demonstrate
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