pcbi.1011655.s008.tif (6.08 MB)
r20 comparison between different models for DHFR, P53 and MTOR.
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posted on 2023-11-27, 19:10 authored by Hoda Akl, Brooke Emison, Xiaochuan Zhao, Arup Mondal, Alberto Perez, Purushottam D. DixitThe average Pearson correlation coefficient between frequencies of top 20 amino acid combinations of order n (x-axis) averaged across different combinations (y-axis). Panel A, protein DHFR, panel B protein P53 and panel C is protein MTOR.
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unlike current methodsstable 3d structuremodeling moderately sizedlow sequence coverageinformative latent spacecorresponding natural ensemblesamino acid covariationgenerative nonlinear tensoraccurate generative modeldiv >< pprotein sequence familiesprotein familiesgenerative modelsprotein scientistsrelated obstacleslarge proteinsimportant toolfactorization engineers alike
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