pone.0258951.g005.tif (2.39 MB)
In vivo studies of radioresistant lung cancer in nude BALB/c mice and its histopathological characterization.
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posted on 2021-11-11, 18:35 authored by Dominic Leiser, Santanu Samanta, John Eley, Josh Strauss, Michael Creed, Tami Kingsbury, Paul N. Staats, Binny Bhandary, Minjie Chen, Tijana Dukic, Sanjit Roy, Javed Mahmood, Zeljko Vujaskovic, Hem D. Shukla(A), Orthotopic mouse model of human A549 lung cancer showed in Cone beam CT image following trans-bronchial inoculation of A549 NSCLC cells in the right lung of nude mice. White arrow shows tumor in lower lobe of right lung. (B), Hematoxylin and eosin (HE) staining of the orthotopic tumor in nude mice; (C), IHC staining of Caveolin-1 in in orthotopic lung tumor created by A549 parental cells. (D), IHC staining of Caveolin-1 in in orthotopic lung tumor created by A549 radio resistant cells. (E), IHC staining of Caveolin-1 in human adenocarcinoma cells; (F), IHC staining of Caveolin-1in human squamous cell carcinoma cells. (G), Quantification of IHC images of radiosensitive and radioresistant mouse tumor tissues.
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stat signaling pathwayslung cancer patientsdiscovered higher levelcomplex multifactorial mechanismheterogeneous tumor siteradiation therapy playsradio sensitive phenotypepresent investigation caveolindiv >< pparental a549 cellsexpressed a549 cellsgene expression analysis1 overexpressed cellsradiation treatment responsea549 parentalhighly expressedenhanced expressiontumor radioresistancetumor progressiontumor aggressiontreatment failureprecision medicinepoor survivalpoor prognosisnsclc ).missense mutationmeasure caveolinmajor causedna damagedemonstrated amplificationcytoskeleton proteinsclonal selectioncas9 knockout950 pg450 pg1 protein1 1 (<
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