pbio.3002486.s002.tiff (365.55 kB)
IL-1β-/- mice co-housed with WT mice are resistant to Salmonella infection.
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posted on 2024-01-18, 18:41 authored by Mor Zigdon, Jasmin Sawaed, Lilach Zelik, Dana Binyamin, Shira Ben-Simon, Nofar Asulin, Rachel Levin, Sonia Modilevsky, Maria Naama, Shahar Telpaz, Elad Rubin, Aya Awad, Wisal Sawaed, Sarina Harshuk-Shabso, Meital Nuriel-Ohayon, Mathumathi Krishnamohan, Michal Werbner, Omry Koren, Sebastian E. Winter, Ron N. Apte, Elena Voronov, Shai Bel(A–D) Salmonella C.F.U. 4 days post-infection in cecal content (A), M.L.N. (B), liver (C), and spleen (D) of co-housed mice infected with 107 C.F.U. Salmonella enterica serovar typhimurium (SL1334) 24 h after pretreatment with 20 mg streptomycin. (E) Survival percentage of mice infected orally with Salmonella. (A–D) Each dot represents a mouse. These data are representative of 1 experiment. *P < 0.05; **P < 0.01; ****P < 0.0001. (A–D) Mann–Whitney test. (E) Mantel–Cox test. C.F.U., colony-forming units; Sep, separately housed; Co, co-housed; d.p.i., days post-infection. Numerical values are in S1 Data.
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sup >-/-reduced tissue damageoutcompete commensal microbesintracellular pathogens likeinactivator carboxypeptidase nfatty acid oxidationepithelial cell metabolismdiv >< pchain fatty acidswitching energy productionprocess via ilestablish gut colonizationacute gastrointestinal infectionmice lacking il1β induces expression1β productionexploits iluninfected patientstyphimurium triggerssalmonella remains unclearrecruit neutrophilsprevented depletionpatients sufferingintestinal defenseinterleukin 1βhealthy individualsfindings identifyexpression correlatescpn1 ).controlling mortality1β signaling1β ).1β (<
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