Daf^-/- mice present overall lower antiviral cytokine response.

Antiviral cytokine levels were measured in BALs of C57BL/6J WT or Daf^-/- mice infected with 1000 PFU of PR8-HK4,6 at 3, 6 and 9 d.p.i. (n = 5 per group). A: interferon (IFN)-α, B: IFN-β, C: IFN-γ, D: interleukin (IL)-1β, E: IL-6, F: IL-10, G: IL-12, H: tumor necrosis factor (TNF)-α, I: granulocyte-macrophage colony-stimulating factor (GM-CSF), J: C-C motif chemokine ligand (CCL) 2, K: CCL5, L: C-X-C motif chemokine ligand (CXCL) 1, M: CXCL10. Results are expressed as mean±sd from at least 2 independent experiments. Statistical analysis detailed in materials and methods.