pone.0259449.g004.tif (107.65 kB)
ATP5E, COX6C and RPL9 overall promoter DNA methylation by MetS status.
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posted on 2021-10-29, 17:37 authored by Keane Urashima, Anastasia Miramontes, Luis A. Garcia, Dawn K. ColettaMean methylation within the promoters of ATP5E, COX6C and RPL9 in non-MetS (n = 110) and MetS (n = 74). Mann-Whitney U test was used for the statistical comparisons between the non-MetS versus MetS. ***p < 0.001, ****p < 0.0001.
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whitney u testtwo cpg sitesthree cpg sitestargeted approach focusingsignificant inverse relationshippresent study aimedimpaired glucose tolerancehighly prevalent worldwidefuture validation studiesepsilon subunit (<arizona insulin resistanceshowed decreased methylationmean methylation within20 decreased genesdiv >< phuman whole bloodlatinos 184 adult participantswhole bloodmethylation dataselect genesadult populationidentify bloodversus rpl9 cox6c atp5e united statesspearman ’smoking statusrpl9 )pyrosequencing analysispromoter regionpotential evidencemultiple phenotypesmolecular mechanismsmetabolic syndromelatino descentincluding obesityestimates showepigenetic biomarkerscox6c )correlation revealedcomplex diseaseatp5e )atp synthaseatp iii05 using05 ).
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