ΔcLD gene pairs in case/control association mapping data: annotation of top genes and enrichment of pathways.

a-b) Group bar charts show the ratio between the number of selected genes being validated in the database dividing the number of genes in the database (q/m) as well as the number of selected genes dividing the total number of all known minus m (k/n). The values on the top of each bar are the p-values of the hypergeometric distribution probability test. The x-axis indicated the top gene pairs using different cutoffs, [200, 500, …, 2,000]. a) DisGeNET database. b) SFARI database. c) a dot plot showing the top 10 KEGG pathways ranked by the GeneRatio values. The size of the balls indicates the number of the genes enriched and the color indicates the level of the enrichment (P-adjusted values). The GeneRatio is calculated as count/setSize. ’count’ is the number of genes that belong to a given gene-set, while ’setSize’ is the total number of genes in the gene-set. d). a bar plot showing the top 10 enriched biological processes ranked by p-values. The correlation is more significant as the red/blue ratio increases. The number on the x-axis indicates the number of genes that belong to a given gene set.