Vitamin B2 biosynthesis pathway in wBm.

(A) Schematic diagram of the riboflavin (vitamin B2) biosynthetic pathway. The various enzymes involved in the pathway and their corresponding genes in E. coli and wBm are shown. (B) Wolbachia ribA gene expression in various developmental stages of B. malayi. RNA from adult female, male, microfilaria, L3 and L4 stages were analyzed. ribA expression is represented relative to Wolbachia 16S rRNA. Data obtained from triplicate samples are expressed as a mean ± standard deviation.