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Up-regulated and down-regulated genes in cholesteatoma.
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posted on 2012-12-20, 00:38 authored by Christin Klenke, Sebastian Janowski, Daniela Borck, Darius Widera, Jörg Ebmeyer, Jörn Kalinowski, Anke Leichtle, Ralf Hofestädt, Tahwinder Upile, Christian Kaltschmidt, Barbara Kaltschmidt, Holger Sudhoff(A) mean log expression value plot. The most prominent hits are shown in red. Microarray analysis revealed that the expression of genes, such as PI3, SPRR1B, LCN2 (lipocalin 2), MMP1, MMP9, MMP10, MMP12, SPP1, GJB2, Bcl-xl (BCL2L1), cIAP2 (BIRC3), S100A7A (koebnerisin), S100A9, SERPINB3, CEACAM6, KRT6B and SERPINB4 is higher in cholesteatoma compared to external auditory canal skin. Genes like TFAP2B, CDH18, CDH19, PRPH, ID4, PAX3, LAMC2, SP5 and FGFBP2 were significantly down-regulated. (B) Up-regulated and down-regulated genes in cholesteatoma, according to biological function. Biological processes, which are denoted with ‘others’ are processes with less than 10 genes involved.
