Figure_7.tif (1.19 MB)
Two approaches to specifically target HSCs.
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posted on 2013-06-18, 01:21 authored by Julia Reetz, Berit Genz, Claudia Meier, Bhavani S. Kowtharapu, Franziska Timm, Brigitte Vollmar, Ottmar Herchenröder, Kerstin Abshagen, Brigitte M. PützerIllustration of different HSC-specific retargeting strategies for adenoviral vectors by linking NGFp, specific for p75NTR, to viral surface proteins via chemical coupling (PEGylation) or adapter molecules (S11). The two different methods lead to masking of distinct viral structures. The “cloud” formed by PEGylation shields the whole virus surface including CAR- and RGD-binding motifs, while coupling of the S11 adapter molecule only screens the virus fiber knob necessary for interaction with CAR.
