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The proposed miR-193a regulatory network.

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posted on 2014-12-29, 20:43 authored by Frank H. C. Cheng, Baltazar D. Aguda, Je-Chiang Tsai, Marek Kochańczyk, Jora M. J. Lin, Gary C. W. Chen, Hung-Cheng Lai, Kenneth P. Nephew, Tzy-Wei Hwang, Michael W. Y. Chan

(A) Activation of estrogen receptor (ER) signaling may increase the increase the transcription of E2F6 which may subsequently increase the expression of c-KIT through miR-193a mediated ceRNA mechanism. On the other hand, in addition to transcriptional repressor, E2F6 may lead to epigenetic silencing of the miR-193a promoter resulting in the up-regulation of c-KIT. The description for each number in the pathway is listed in S1 Table. (B) The biochemical interaction for this proposed miR-193a regulatory network. Model variables names for molecule species are also given.