The HCP clusters are more robust against perturbations to its architecture than the SCP clusters.

At normal coupling strength of g_c = 200 pS (left columns), both cluster types are robust against up to 50% β-cell loss in the cluster. When the coupling is compromised with reduced g_c values (middle and right columns), the SCP clusters are more affected by β-cell loss. Dashed lines are the mean and the 2 standard deviations (SD) of completely uncoupled β cells.