Figure_8.tif (2.16 MB)
Suppression of the GMR-hid-eye ablation phenotype by ESCRT-II mosaics.
figure
posted on 2013-02-21, 07:14 authored by Hans-Martin Herz, Sarah E. Woodfield, Zhihong Chen, Clare Bolduc, Andreas Bergmann(A) Expression of the pro-apoptotic gene hid under control of the eye-specific GMR enhancer (GMR-hid) gives rise to a strong eye ablation phenotype due to excessive apoptosis. (B–D) vps25N55 (C) and vps36L5212 (D) eye mosaics are strong suppressors of the GMR-hid-induced eye ablation phenotype in adult flies. vps225F8-3 mosaics (B) do not suppress the GMR-hid-eye ablation phenotype. Genotypes: (A) eyFlp ; GMR-hid; FRT82B/FRT82B P[w+]. (B) eyFlp; GMR-hid; FRT82B vps225F8-3/FRT82B P[w+]. (C) GMR-hid eyFlp; FRT42D vps25N55/FRT42D P[w+]. (D) eyFlp; GMR-hid; vps36L5212 FRT2A/P[w+] FRT2A.
