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Resveratrol reduces superoxide generation and enhances NO production in senescent endothelial cells.

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posted on 2013-02-20, 19:07 authored by Angana G. Rajapakse, Gautham Yepuri, João M. Carvas, Sokrates Stein, Christian M. Matter, Isabelle Scerri, Jean Ruffieux, Jean-Pierre Montani, Xiu-Fen Ming, Zhihong Yang

Young and senescent HUVEC cells were treated with solvent as control (C), resveratrol (Resv, 10 µmol/L) or rapamycin (Rapa, 20 ng/ml) for one hour and then subjected to (A) MitoSox, (B) DHE, and (C) DAF-2DA staining. Quantification of the signals from six independent experiments is shown in the corresponding right panels. *p<0.05, **p<0.01 and ***p<0.001 between indicated groups. Scale bar = 0.2 mm.