Representative images of eye phenotype of aged heterozygous Foxf2^W174R mutant mice.

A, 6 month old Foxf2^W174R eye (m+/) showing normal retinal termination at the edge of the optic nerve fibre layer (black arrows). B&C, sections through two other 6 month old Foxf2^W174R eyes showing abnormal bulge in the nerve fibre layer. The outer nuclear layer of the retina can be seen to continue at the surface of this bulging tissue (white arrows). D&E, retinal sections in 6 month eyes. F&G, corneal sections in 6 month eyes. H–J, 12 month Foxf2^W174R optic nerves that do not show signs of glaucomatous change. v, vein; p, photoreceptors; onl, outer nuclear layer; inl, inner nuclear layer; ce, corneal epithelium; cs, corneal stroma. Scale bar  = 50 µm.